"My focus in 2019 will not be on professional basketball, but will instead be on the people in my family, as well as on investing my time in some ministry dreams that have been stirring in my heart for many years," Moore wrote in The Players' Tribune.
The 29-year-old has led the Lynx to the WNBA title in four of her eight seasons since being selected No. 1 overall in the 2011 draft. She was named the league's MVP for the 2014 campaign.
"I'm thankful to my Lynx family and others close to me who have been walking with me during this shift, and I’m excited to see what the future holds," Moore added.
Through eight seasons, Moore has averaged 18.4 points, 5.9 rebounds, 3.3 assists, and 1.7 steals in 31.2 minutes per game.