The Broncos listed Lock as questionable Friday due to a rib injury. After missing Wednesday's practice, the signal-caller had limited training participation in the last two days.
The 24-year-old has struggled in his second NFL campaign, completing 55% of his pass attempts while throwing for just seven touchdowns against 10 interceptions.
Lock has missed two games due to injury this season.
The 3-6 Broncos will try to snap a two-game losing streak in Week 11.